In 2017 there were seven Unisa regional centres or 'hubs' in full operation. Eastern and Western Cape, Gauteng, KZN, Midlands, Limpopo and Mpumalanga, with regional head offices in East London, Cape Town, Sunnyside (Pretoria), Durban, Rustenburg, Polokwane and Nelspruit respectively The hubs, in turn, were responsible for the operations of smaller service centres or agencies. The regional hubs and service centres offered administrative and student (academic) support and advice, library services and career counselling.
The Unisa regional model represents a remarkable venture to bring university education to students across the country, especially those in more remote and rural districts.