Dr MG Smith

Expertise

• Chemistry
• Chemometrics
• Crystallography
• Raman
• Spectroscopy
• XRD

Qualifications

• PhD Chemistry (Wits)
• MSc Chemistry (Unisa)
• BSc Hons Chemistry (Unisa)
• BSc Chemistry and Biochemistry (Unisa)
• Advanced Outcomes Based Assessment (Unisa)

Currently teaching

• PCH241P – Physical Chemistry for Engineers II (Theory)
• PCH2PRA – Physical Chemistry for Engineers II (Practical)
• CHE4805 – Structural Chemistry Honours (Theory)
• CHE4808 – Honours Research Methodology (Project)

Fields of academic interests

• Crystal and Co-Crystal Engineering of Active Pharmaceutical Ingredients
• Structural and Supramolecular Chemistry
• Single Crystal X-Ray Crystallography

Field of Specialisation

• Supramolecular Chemistry
• Structural Chemistry
• Crystal and co-crystal Engineering
• Crystallography
• Single Crystal XRD
• Pharmaceutical Drug Design

Journal articles

The crystal structure of 4-phenyl-4-[2-(pyridine-4-carbonyl)hydrazinylidene]butanoic acid, C₁₆H₁₅N₃O₃
Itumeleng B. Setshedi, Mark G. Smith
Zeitschrift für Kristallographie - New Crystal Structures, 2022, 237(1), 133-134; DOI: 10.1515/ncrs-2021-0429  

The crystal structure of (E)-N’-(butan-2-ylidene)isonicotinohydrazide 0.5 hydrate, C₁₀H₁₃N₃O·0.5H₂O
Itumeleng B. Setshedi, Andreas Lemmerer; Mark G. Smith
Zeitschrift für Kristallographie - New Crystal Structures, 2021, 236(6), 1295-1296; DOI: 10.1515/ncrs-2021-0311  

The crystal structure of the co-crystal: 2-hydroxybenzoic acid -N’-(butan-2-ylidene)pyridine-4-carbohydrazide, C₁₀H₁₃N₃O·C₇H₆O₃
Itumeleng B. Setshedi, Mark G. Smith
Zeitschrift für Kristallographie - New Crystal Structures, 2021, 236(5), 1093-1095; DOI: 10.1515/ncrs-2021-0232  

Novel crystal forms of 4-aminoantipyrine and its derivatives: Co-crystallizing a reluctant molecule
Mark G. Smith, Andreas Lemmerer
J. Mol. Struct. 2019, 1175, 307-313; DOI: 10.1016/j.molstruc.2018.07.062

The photodimerization of Schiff bases: Synthesis and crystal structures of benzophenone azines and their weak C-H···π interactions
Mark G. Smith, Andreas Lemmerer
J. Mol. Struct. 2019, 1179, 132-144; DOI: 10.1016/j.molstruc.2018.10.038

Covalent Assisted Supramolecular Synthesis: The Influence of Crystallization Conditions on Co-Crystals of “Masked” Isoniazid Derivatives
Mark G. Smith, Andreas Lemmerer
Cryst. Growth Des. 2018, 18, 4777-4789; DOI: 10.1021/acs.cgd.8b00871

Enhancing Student Performance in First Year Chemistry Through Web-Based Learning in an Open Distance University Context Hadley S. Clayton, Mark G. Smith
Progressio 2016, 38, 74-86 ; DOI: 10.25159/0256-8853/1048

Covalent Assisted Supramolecular Synthesis: Masking of Amides in Co-Crystal Synthesis using Benzophenone Derivatives
Mark G. Smith, Roy P. Forbes, Andreas Lemmerer
Cryst. Growth Des. 2015, 15, 3813-3821; DOI: 10.1021/acs.cgd.5b00462

Paper presentations

• Covalent Assistance to Supramolecular Synthesis
  Andreas Lemmerer, Lee Madeley, Mark Gordon Smith
  Acta Crystallographica Section A: Foundations and Advances 2014, 70(a1):C987-C987; DOI: 10.1107/S2053273314090123

Professional positions, fellowships & awards

• Dr. Smith is currently the Chairperson of the South African Chemical Institute (SACI) Central Division.

Projects

• Crystal and Co-Crystal Engineering of Active Pharmaceutical Ingredients.
• Metal-organic crystals of Active Pharmaceutical Ingredients.
• Co-crystal growth, design and structural studies.

Other

Thuthuka Grantholder for the research project entitled: "Crystal Engineering, Co-crystal Engineering, and synergy studies of modified isoniazid".